Improving methods to measure important metabolites in heart surgery patients
Official title: Development, Validation, and Harmonization of Methods for Collection and Measurement of NAD+ and Related Metabolites: Application to a Randomized Trial of Patients Undergoing Coronary Artery Bypass
Funded at Brigham and Women's Hospital · NIH-10977149 · Data updated 2026-11-12
This study is working on improving how we collect and measure important substances in your body during heart surgery, which can help us better understand your energy levels and improve your care.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $1,020,661 |
| NIH project number | 1U01AG089040-01 |
| Project ID | NIH-10977149 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who are scheduled to undergo coronary artery bypass surgery.
✕Less likely to help
Patients who are not undergoing coronary artery bypass surgery or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on developing and validating better methods for collecting and measuring NAD+ and related metabolites in patients undergoing coronary artery bypass surgery. The team will optimize sample collection and storage protocols to ensure the integrity of these metabolites, which are crucial for understanding cellular energy processes. They will also enhance an advanced method called LC-MS/MS that allows for precise measurement of these metabolites in human tissues. By addressing current limitations in measurement techniques, this research aims to provide more accurate data that could inform patient care.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and treatment strategies for patients undergoing heart surgery.
How similar studies have gone: Previous research has shown success in improving metabolite measurement techniques, indicating potential for this approach to yield valuable insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Bhasin, Shalender — Brigham and Women's Hospital
- Study coordinator: Bhasin, Shalender
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.