Improving methods to measure important metabolites in heart surgery patients
Development, Validation, and Harmonization of Methods for Collection and Measurement of NAD+ and Related Metabolites: Application to a Randomized Trial of Patients Undergoing Coronary Artery Bypass
['FUNDING_U01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10977149
This study is working on improving how we collect and measure important substances in your body during heart surgery, which can help us better understand your energy levels and improve your care.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10977149 on ClinicalTrials.gov |
What this research studies
This research focuses on developing and validating better methods for collecting and measuring NAD+ and related metabolites in patients undergoing coronary artery bypass surgery. The team will optimize sample collection and storage protocols to ensure the integrity of these metabolites, which are crucial for understanding cellular energy processes. They will also enhance an advanced method called LC-MS/MS that allows for precise measurement of these metabolites in human tissues. By addressing current limitations in measurement techniques, this research aims to provide more accurate data that could inform patient care.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who are scheduled to undergo coronary artery bypass surgery.
Not a fit: Patients who are not undergoing coronary artery bypass surgery or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and treatment strategies for patients undergoing heart surgery.
How similar studies have performed: Previous research has shown success in improving metabolite measurement techniques, indicating potential for this approach to yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BHASIN, SHALENDER — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: BHASIN, SHALENDER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.