Improving methods to control brain circuits in primates using viral vectors
Enhancement, mapping, and validation of viral vectors for primate optogenetics
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-11004969
This study is looking at new ways to deliver genes that help control brain cells in monkeys, which could help us better understand brain disorders and create new treatments, especially for issues related to vision and movement.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11004969 on ClinicalTrials.gov |
What this research studies
This research aims to enhance the delivery of genes that control neurons in the primate brain, which is crucial for understanding brain disorders and developing new therapies. By using advanced viral vectors, the project seeks to overcome challenges related to immune responses that have hindered previous efforts. The focus is on mapping visual and motor circuits in the macaque brain, utilizing specific viruses to ensure targeted and effective gene expression. This approach could lead to more precise interventions in brain function and behavior.
Who could benefit from this research
Good fit: Ideal candidates for participation would include individuals with specific brain disorders that could benefit from targeted gene therapy approaches.
Not a fit: Patients with conditions unrelated to the visual or motor circuits of the brain may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in treating brain disorders by enabling more effective gene therapies.
How similar studies have performed: While there have been successful applications of similar techniques in smaller animal models, this approach in primates is relatively novel and untested.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SOMMER, MARC A — DUKE UNIVERSITY
- Study coordinator: SOMMER, MARC A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.