Improving methods for analyzing treatment effectiveness in ongoing systematic reviews
Advanced Methods and Software for Trial Sequential Analysis in Living Systematic Reviews
['FUNDING_R21'] · UNIVERSITY OF ARIZONA · NIH-11077295
This study is working on ways to keep treatment information up-to-date and reliable, especially for COVID-19, so that doctors can make better choices about therapies, which means patients can get the most effective treatments and avoid those that might not help or could be harmful.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-11077295 on ClinicalTrials.gov |
What this research studies
This research focuses on enhancing the methods used in living systematic reviews (LSRs) to provide timely and reliable evaluations of treatment benefits and risks, particularly in the context of the COVID-19 pandemic. It aims to address the limitations of traditional systematic reviews by continuously updating evidence and utilizing trial sequential analysis (TSA) to ensure that treatment decisions are based on the most current data. By improving the accuracy of these analyses, the research seeks to help healthcare providers make informed decisions about therapies and interventions. Patients may benefit from more effective treatments and reduced exposure to ineffective or harmful options.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients involved in ongoing clinical trials or those affected by conditions being evaluated in living systematic reviews.
Not a fit: Patients who are not participating in clinical trials or whose conditions are not covered by the systematic reviews may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and timely treatment recommendations, ultimately improving patient outcomes.
How similar studies have performed: Previous research has shown that improving systematic review methodologies can enhance treatment decision-making, indicating a promising potential for this approach.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIN, LIFENG — UNIVERSITY OF ARIZONA
- Study coordinator: LIN, LIFENG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, Communicable Diseases, coronavirus disease 2019 crisis, coronavirus disease 2019 epidemic