Improving methadone dosing for opioid addiction treatment
Methadone Dosing System (MDS)
This study is working on a new way to personalize methadone treatment for people recovering from opioid addiction, so that the dose fits each person's unique metabolism, helping them feel better and stay in treatment longer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cari Health, INC. NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project ID | NIH-10792827 on NIH RePORTER |
What this research studies
This research focuses on enhancing the effectiveness of methadone treatment for patients overcoming opioid addiction by developing a new dosing system that accounts for individual metabolic differences. Current dosing practices often lead to inadequate treatment responses due to the variability in how patients metabolize methadone. The project aims to create a more personalized dosing algorithm that can better manage withdrawal symptoms and improve treatment retention. By utilizing genetic and metabolic data, the goal is to optimize methadone dosing for each patient, potentially reducing relapse rates.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals undergoing treatment for opioid use disorders who are currently prescribed methadone.
Not a fit: Patients who are not currently receiving methadone treatment or those with contraindications to methadone will not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective methadone treatments, reducing withdrawal symptoms and improving recovery outcomes for patients with opioid use disorders.
How similar studies have performed: Previous research has shown that personalized medicine approaches can significantly improve treatment outcomes in various medical fields, suggesting potential success for this novel methadone dosing strategy.
Where this research is happening
San Diego, United States
- Cari Health, INC. — San Diego, United States (Active)
Researchers
- Principal investigator: Schmidle, Patrik — Cari Health, INC.
- Study coordinator: Schmidle, Patrik
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.