Improving Metabolism in Propionic Acidemia with Triacetin
Triacetin Treatment for Propionic Acidemia by Rebalancing the Acetyl-CoA/Propionyl-CoA Metabolism
This project looks at whether a supplement called triacetin can help balance metabolism in people with propionic acidemia.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11166616 on NIH RePORTER |
What this research studies
Propionic acidemia (PA) is a rare genetic condition where the body struggles to process certain proteins, leading to harmful build-up and various health problems. Even with special diets, many patients face serious complications. This research explores a new approach using triacetin, a common food additive, to help correct a metabolic imbalance in PA. By boosting a key molecule called acetyl-CoA, triacetin aims to improve energy use and reduce toxic substances in the body. The goal is to find a novel, effective way to manage this challenging disease.
Who could benefit from this research
Good fit: This research is focused on understanding and potentially treating propionic acidemia, a rare metabolic disease caused by specific genetic mutations.
Not a fit: Patients without propionic acidemia or similar metabolic imbalances would not directly benefit from this specific treatment approach.
Why it matters
Potential benefit: If successful, this approach could offer a new, effective, and systemic way to manage propionic acidemia, potentially reducing complications and improving quality of life for patients.
How similar studies have performed: Preliminary findings in mouse models suggest that similar acetate supplementation can improve metabolic balance and survival, providing a basis for this new approach with triacetin.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Zhang, Guofang — Duke University
- Study coordinator: Zhang, Guofang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.