Improving memory in older adults by enhancing brain protein recycling
Alleviating age-related memory impairment through proteasome stimulation
This study is looking at how boosting a part of the brain that helps recycle proteins might improve memory problems that come with aging, and it's aimed at older adults who want to enhance their memory and reduce the risk of Alzheimer's disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-10811380 on NIH RePORTER |
What this research studies
This research investigates how stimulating the proteasome, a key component in the brain's protein recycling system, can help alleviate memory impairments associated with aging. The study focuses on understanding the neurobiological changes that occur in the brain as people age, particularly in the hippocampus, which is crucial for memory formation. By exploring the relationship between proteasome activity and memory function, the research aims to identify potential therapeutic strategies to enhance cognitive abilities in older adults. Patients may be involved in trials that assess the effectiveness of new treatments designed to improve memory and reduce the risk of Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those over the age of 65, who are experiencing memory impairments.
Not a fit: Patients who are not experiencing age-related memory issues or who have advanced Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve memory function in older adults and reduce the risk of developing Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in enhancing cognitive function through proteasome stimulation, indicating potential for success in this approach.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Trask, Sydney — Purdue University
- Study coordinator: Trask, Sydney
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.