Improving memory in aging by targeting brain cell growth regulation
Targeting neurogenesis-inhibition coupling to improve memory in aging
This study is looking at how the brain's ability to create new brain cells can help improve memory in older adults who are having trouble remembering things, and it will explore new ways to boost this process to support better memory in aging individuals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11087555 on NIH RePORTER |
What this research studies
This research investigates how the brain's ability to generate new neurons affects memory, particularly in older adults experiencing cognitive decline. It focuses on the hippocampus, a brain region crucial for forming memories, and examines how certain inhibitory neurons may influence this process. By developing a method to enhance the coupling of neurogenesis and inhibition, the study aims to improve memory consolidation in aging individuals. Patients may be involved in testing new approaches that could help mitigate age-related memory issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing age-related cognitive decline or mild cognitive impairment.
Not a fit: Patients with significant cognitive impairments unrelated to aging or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance memory function in older adults.
How similar studies have performed: Previous research has shown promising results in enhancing cognitive function through neurogenesis, suggesting potential for success in this novel approach.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Sahay, Amar — Massachusetts General Hospital
- Study coordinator: Sahay, Amar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.