Improving memory and brain function in early schizophrenia using brain stimulation
Enhancing prefrontal oscillatory activity and working memory performance with noninvasive brain stimulation in early-course schizophrenia
This study is looking at how gentle brain stimulation can help improve memory and thinking skills in people with early-stage schizophrenia by focusing on a specific part of the brain, and it aims to find new ways to support those facing challenges with their cognitive abilities.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10895550 on NIH RePORTER |
What this research studies
This research investigates how noninvasive brain stimulation techniques can enhance brain activity in individuals with early-stage schizophrenia, particularly focusing on the dorsolateral prefrontal cortex (DLPFC). By using methods like Transcranial Magnetic Stimulation (TMS) combined with EEG, the study aims to determine if boosting the oscillatory activity in this brain region can lead to improvements in working memory performance. Participants will undergo sessions of brain stimulation to assess changes in cognitive function over time. The goal is to provide a new treatment approach that could help mitigate cognitive impairments associated with schizophrenia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with early-course schizophrenia who are experiencing cognitive impairments.
Not a fit: Patients with chronic schizophrenia or those who do not have cognitive disturbances may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cognitive function and quality of life for patients with early-stage schizophrenia.
How similar studies have performed: Previous research has shown promising results using similar brain stimulation techniques to enhance cognitive function in various populations, suggesting potential for success in this novel application.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Ferrarelli, Fabio — University of Pittsburgh at Pittsburgh
- Study coordinator: Ferrarelli, Fabio
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.