Improving medications for alcohol use disorder
Official title: Optimization of Drug-like Properties of CRFBP-CRF2 Negative Allosteric Modulators for Alcohol Use Disorder
Funded at Sanford Burnham Prebys Medical Discovery Institute · NIH-10931763 · Data updated 2026-11-12
This study is looking at new medications to help adults who are dealing with Alcohol Use Disorder by focusing on how certain compounds can better interact with the brain's stress response, aiming to create more effective treatments for those who want to reduce their alcohol use.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $800,043 |
| NIH project number | 5R01AA030888-02 |
| Project ID | NIH-10931763 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are struggling with Alcohol Use Disorder.
✕Less likely to help
Patients who do not have Alcohol Use Disorder or are under 21 years old may not benefit from this research.
What this research studies
This research focuses on developing new medications to treat Alcohol Use Disorder (AUD), a condition affecting millions of adults. The approach involves optimizing specific compounds that interact with the brain's stress response system, particularly targeting a protein that influences alcohol consumption. By understanding how this protein works, researchers aim to create more effective treatments that could help individuals struggling with AUD. The study will explore the mechanisms of these compounds to enhance their drug-like properties and efficacy.
Why it matters
Potential benefit: If successful, this research could lead to more effective medications for individuals with Alcohol Use Disorder, improving their chances of recovery.
How similar studies have gone: Previous research has shown promise in targeting the stress response system for treating addiction, indicating potential for success in this novel approach.
Where this research is happening
-
Sanford Burnham Prebys Medical Discovery Institute
La Jolla, United States Active
Researchers
- Principal investigator: Sheffler, Douglas J — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Sheffler, Douglas J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.