Improving Medication Timing for Cardiac Arrest
Optimizing the Timing and Route of Antiarrhythmic Administration in Out-of-Hospital Cardiac Arrest
['FUNDING_OTHER'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-11080888
This research looks at whether giving heart rhythm medications earlier can help more people survive sudden cardiac arrest outside the hospital.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-11080888 on ClinicalTrials.gov |
What this research studies
When someone experiences a sudden cardiac arrest, their heart stops beating effectively, and survival rates are often low, especially if initial electric shocks don't work. Current guidelines suggest waiting to give certain heart rhythm medications until after several shocks, which might delay effective treatment. This project aims to see if giving these medications sooner, and considering how they are given, could lead to better outcomes for patients. We hope to understand if a change in the timing of these life-saving drugs can significantly improve survival.
Who could benefit from this research
Good fit: This research is relevant for individuals who experience out-of-hospital cardiac arrest caused by specific abnormal heart rhythms like ventricular fibrillation or pulseless ventricular tachycardia.
Not a fit: Patients experiencing cardiac arrest due to other causes, or those who do not receive immediate medical attention, may not directly benefit from this specific approach.
Why it matters
Potential benefit: If successful, this work could lead to updated guidelines for emergency care, potentially saving more lives after sudden cardiac arrest.
How similar studies have performed: Current guidelines already use antiarrhythmic drugs for cardiac arrest, but this research explores whether changing the timing and sequence of their administration could be more effective.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LUPTON, JOSHUA — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: LUPTON, JOSHUA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.