Improving medication adherence for people with bipolar disorder

Effectiveness RCT of Customized Adherence Enhancement

NIH-funded research Case Western Reserve University · NIH-10816477

This study is looking to help people with bipolar disorder stick to their medication by finding out what makes it hard for them and offering personalized support, making it easier for them to manage their treatment in everyday settings.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionCase Western Reserve University NIH-funded
Lab location1 site (Cleveland, United States)
Project IDNIH-10816477 on NIH RePORTER

What this research studies

This research focuses on enhancing medication adherence among individuals with bipolar disorder (BD) through a tailored approach called Customized Adherence Enhancement (CAE). The study aims to identify specific barriers that patients face in adhering to their medication regimens and provide targeted interventions to address these challenges. By utilizing a flexible, modular format, the research will adapt CAE for use in community care settings, making it more accessible and practical for patients. The effectiveness of this approach will be evaluated through a randomized controlled trial comparing CAE to standard education on bipolar disorder.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals diagnosed with bipolar disorder who struggle with medication adherence.

Not a fit: Patients who are already consistently adhering to their medication regimen may not receive additional benefit from this research.

Why it matters

Potential benefit: If successful, this research could significantly improve medication adherence and overall functioning for patients with bipolar disorder.

How similar studies have performed: Previous research has shown promising results with similar adherence enhancement approaches, indicating potential for success in this adapted model.

Where this research is happening

Cleveland, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions bipolar affective disorderbipolar diseasemanic depressive disorder
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.