Improving measurement of immune proteins in cerebrospinal fluid for children with brain tumors
Optimizing pre-analytical variables for reliable mass spectrometry-based quantification of immunomodulatory proteins in cerebrospinal fluid in pediatric neuro-oncology trials
This study is working to improve how we measure immune proteins in the spinal fluid of kids with brain tumors, so we can better track how well new treatments are working and make sure they fit each child's needs.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11010279 on NIH RePORTER |
What this research studies
This research focuses on enhancing the accuracy of measuring immune proteins in cerebrospinal fluid (CSF) from pediatric patients with brain tumors. It aims to identify and reduce factors that can affect the reliability of these measurements, which are crucial for monitoring the effectiveness of new immune therapies. By developing a standardized protocol for handling CSF samples, the study seeks to ensure that the data collected during clinical trials is consistent and reliable. This will help in understanding how well patients respond to treatments and in tailoring therapies to individual needs.
Who could benefit from this research
Good fit: Ideal candidates for this research are pediatric patients diagnosed with brain tumors who are participating in clinical trials involving immune therapies.
Not a fit: Patients with brain tumors who are not enrolled in clinical trials or those receiving standard treatments without immune therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective monitoring of treatment responses in children with brain tumors, ultimately improving patient outcomes.
How similar studies have performed: Previous research has shown promise in optimizing measurement techniques for biomarkers in other conditions, suggesting that this approach could yield valuable insights in pediatric neuro-oncology as well.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Paulovich, Amanda G — Fred Hutchinson Cancer Center
- Study coordinator: Paulovich, Amanda G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.