Improving lymphatic vessel function to treat lymphedema
Official title: Lymphatic Regeneration by Direct Cellular Reprogramming
Funded at Emory University · NIH-10841615 · Data updated 2026-11-12
This study is exploring a new way to help people with lymphedema by turning regular cells into special cells that can repair lymphatic vessels, aiming to offer a safer and more effective treatment option.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $510,498 |
| NIH project number | 5R01HL166817-02 |
| Project ID | NIH-10841615 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with lymphedema or those at risk of developing this condition due to lymphatic dysfunction.
✕Less likely to help
Patients with lymphedema caused by irreversible damage or those who do not have functional lymphatic tissue may not benefit from this research.
What this research studies
This research focuses on developing a new method to regenerate lymphatic vessels, which are crucial for fluid balance and immune function in the body. By using a technique called direct cellular reprogramming, the researchers aim to convert regular cells into specialized lymphatic endothelial cells that can help alleviate conditions like lymphedema. This approach seeks to provide a more effective and safer treatment option compared to existing therapies, which are often limited and invasive. Patients may benefit from this innovative method that could lead to improved lymphatic function and reduced symptoms of lymphedema.
Why it matters
Potential benefit: If successful, this research could provide a novel treatment option for patients suffering from lymphedema, potentially improving their quality of life.
How similar studies have gone: While direct cellular reprogramming is a relatively novel approach, preliminary studies have shown promise in similar applications for other conditions, indicating potential for success in this area.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Yoon, Young-Sup — Emory University
- Study coordinator: Yoon, Young-Sup
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.