Improving lymphatic function by controlling a specific signaling pathway
Official title: Controlling Neuropilin-2 Signaling to Improve Lymphatic Function
Funded at Boston Children's Hospital · NIH-11107019 · Data updated 2026-11-12
This study is looking at how a protein called Neuropilin-2 affects the lymphatic system, which helps with fluid balance and immune health, to find better ways to treat conditions like lymphedema and other chronic illnesses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 5, 2025 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $865,694 |
| NIH project number | 1R01HL179216-01 |
| Project ID | NIH-11107019 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing lymphatic dysfunction or related chronic conditions.
✕Less likely to help
Patients with no lymphatic issues or those outside the age range of 21+ years may not benefit from this research.
What this research studies
This research investigates how Neuropilin-2 (NRP2) affects lymphatic function, which is crucial for fluid recycling and immune response. By manipulating NRP2 signaling in lymphatic endothelial cells, the research aims to enhance lymphatic drainage and lipid uptake, potentially alleviating conditions like lymphedema and other chronic illnesses. The approach involves innovative biochemical and genomic techniques, as well as new animal models, to understand and control the signaling pathways associated with NRP2. Patients may benefit from new therapeutic strategies that improve lymphatic health and function.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve lymphatic function and reduce complications from chronic illnesses.
How similar studies have gone: Previous research has shown promise in manipulating lymphatic signaling pathways, indicating potential for success in this novel approach.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Bielenberg, Diane Renee — Boston Children's Hospital
- Study coordinator: Bielenberg, Diane Renee
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.