Improving lung cancer screening using advanced imaging and genetic markers
Lung cancer screening efficacy enhanced through radiomic and epigenetic biomarkers
This study is looking for better ways to spot lung cancer in people who have a history of smoking by using special imaging and genetic information, so we can tell the difference between harmful and harmless lung nodules more easily.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10845285 on NIH RePORTER |
What this research studies
This research investigates how to enhance lung cancer screening by using advanced imaging techniques and genetic markers. It focuses on patients with a significant smoking history, utilizing low-dose computed tomography (LDCT) to identify lung nodules. The study aims to differentiate between malignant and benign nodules more effectively by analyzing radiological data and incorporating epigenetic biomarkers related to smoking. By employing machine learning algorithms, the research seeks to predict lung cancer risk and assess lung health more accurately.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with a history of heavy smoking, specifically those with at least 30 pack years.
Not a fit: Patients who do not have a significant smoking history or those without lung nodules may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate lung cancer screenings, potentially saving lives through earlier detection.
How similar studies have performed: Previous studies have shown promise in using imaging and genetic markers for cancer detection, indicating that this approach could be effective.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Sieren, Jessica C — University of Iowa
- Study coordinator: Sieren, Jessica C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.