Improving lung cancer screening for smokers using DNA analysis
Official title: An Improved Epigenetic Algorithm for Guiding Low Dose CT Lung Cancer Screening
Funded at Bd Holding, INC. · NIH-10890199 · Data updated 2026-11-12
This study is looking at how to make lung cancer screening with low-dose CT scans better for smokers by using special DNA tests to find out who would benefit the most from the screening, helping to catch lung cancer earlier and improve treatment options.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Bd Holding, INC. NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $985,125 |
| NIH project number | 5R44CA285136-02 |
| Project ID | NIH-10890199 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are current or recent smokers aged 50 to 80 who have a significant smoking history of 20 pack years or more.
✕Less likely to help
Patients who have never smoked or those outside the specified age range may not benefit from this research.
What this research studies
This research focuses on enhancing the effectiveness of Low Dose Computerized Tomography (LDCT) for lung cancer screening in smokers by utilizing advanced epigenetic algorithms. The study aims to identify which smokers are most likely to benefit from LDCT screening based on their DNA methylation patterns. By analyzing specific genetic markers, the research seeks to develop a more precise method for determining eligibility for screening, potentially leading to earlier detection and better treatment outcomes for lung cancer. The approach combines cutting-edge technology with established biomarkers to refine screening recommendations.
Why it matters
Potential benefit: If successful, this research could lead to more targeted and effective lung cancer screening for smokers, improving early detection and treatment outcomes.
How similar studies have gone: Previous studies have shown promising results using similar epigenetic approaches to predict smoking status and screening benefits, indicating a strong potential for success in this research.
Where this research is happening
-
Bd Holding, INC.
Iowa City, United States Active
Researchers
- Principal investigator: Philibert, Robert a — Bd Holding, INC.
- Study coordinator: Philibert, Robert a
Related research
Other NIH-funded projects on the same topics.
-
Digital health strategies to expand lung cancer screening in safety-net clinics
A funded project aims to help low-resource clinics increase the use of lung cancer screening for patients who smoke or are at risk.
-
Integrated approach to lung screening and quitting for African Americans
A multi-level program aims to boost LDCT lung cancer screening uptake and help African American smokers quit, with support from a comprehensive community-focused plan.
-
Population health approach to boost lung cancer screening at community clinics
A large Utah project aims to help community clinics reach more eligible adults to get low-dose CT lung cancer screening.
-
Group-based tobacco treatment for older adults after lung cancer screening
A study tests a group-based tobacco cessation program for older adults who are getting lung cancer screening to help them quit smoking.
-
Personalized Lung Cancer Screening for Veterans
Aimed at improving who gets screened and how lung cancer is diagnosed among Veterans using personalized tools.
-
Proteogenomic framework to improve lung cancer screening with biomarkers
A biomarker-based approach aims to refine LDCT lung cancer screening so more cancers are caught early while reducing unnecessary procedures.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.