Improving long-term acceptance of transplanted organs
Targeting monocyte allorecognition to achieve allograft acceptance
This study is looking at ways to help your body accept transplanted organs better and for longer by focusing on certain immune cells, so you might not need to take as many medications to prevent rejection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11049207 on NIH RePORTER |
What this research studies
This research focuses on enhancing the long-term acceptance of transplanted organs by targeting specific immune responses. It investigates how monocytes, a type of immune cell, recognize and respond to transplanted tissues, particularly through a molecule called CD47. By blocking this recognition process alongside T cell costimulation, the research aims to reduce the risk of chronic rejection and eliminate the need for ongoing immunosuppressive therapy. This approach could lead to more successful and sustainable organ transplants for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals undergoing organ transplantation, particularly those at risk of chronic rejection.
Not a fit: Patients who have already experienced severe graft failure or those not eligible for organ transplantation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the longevity and success of organ transplants, reducing the need for lifelong immunosuppression.
How similar studies have performed: Previous research has shown promise in similar approaches targeting immune responses in transplantation, suggesting potential for success in this novel strategy.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Oberbarnscheidt, Martin H — University of Pittsburgh at Pittsburgh
- Study coordinator: Oberbarnscheidt, Martin H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.