Improving long-lasting pain relief after surgery with new anesthetic formulations
Official title: Extending duration of an injectable long-acting local anesthetic formulation using novel salts
Funded at Rebel Medicine INC · NIH-10922483 · Data updated 2026-11-12
This study is testing a new type of injectable pain relief for people having surgery, aiming to help them feel better for longer without needing strong painkillers that can have unwanted side effects.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rebel Medicine INC NIH-funded |
| Lab location | 1 site (Salt Lake City, UNITED STATES) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $295,921 |
| NIH project number | 1R43DA059315-01A1 |
| Project ID | NIH-10922483 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients scheduled for surgical procedures who are at risk of experiencing acute postoperative pain.
✕Less likely to help
Patients who are not undergoing surgery or those who do not experience acute pain may not benefit from this research.
What this research studies
This research focuses on developing a new injectable formulation of local anesthetics that can provide extended pain relief after surgical procedures. By using novel salts, the goal is to prolong the duration of pain control, reducing the reliance on opioid medications, which are often associated with serious side effects and addiction. Patients undergoing surgery typically experience acute pain, and this research aims to enhance their recovery experience by minimizing the need for systemic pain medications. If successful, this approach could lead to safer postoperative pain management strategies.
Why it matters
Potential benefit: If successful, this research could significantly reduce the need for opioid medications in postoperative care, thereby decreasing the risk of addiction and other adverse effects.
How similar studies have gone: Other research has shown promise in developing long-acting local anesthetics, but this specific approach using novel salts is relatively novel and untested.
Where this research is happening
-
Rebel Medicine INC
Salt Lake City, United States Active
Researchers
- Principal investigator: Davis, Brett — Rebel Medicine INC
- Study coordinator: Davis, Brett
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.