Improving liver preservation to extend donor organ availability
Enhanced supercooling for extending non-freezing preservation in preclinical porcine and human donor livers
['FUNDING_SBIR_2'] · SYLVATICA BIOTECH, INC. · NIH-11008882
This study is looking at a new way to keep donor livers healthy for longer so they can be transported farther, which could help more people who need a liver transplant.
Quick facts
| Phase | ['FUNDING_SBIR_2'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SYLVATICA BIOTECH, INC. (nih funded) |
| Locations | 1 site (NORTH CHARLESTON, UNITED STATES) |
| Trial ID | NIH-11008882 on ClinicalTrials.gov |
What this research studies
This research focuses on enhancing the preservation of donor livers to extend the time they can remain viable outside the body. By using a technique called supercooling, the researchers aim to keep livers at temperatures below freezing without forming ice, which can damage the organs. This could allow for longer transportation times and broader geographic sharing of donor organs, ultimately increasing the chances for patients in need of a liver transplant. The approach involves innovative methods to maintain organ viability during extended storage periods.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from acute liver failure who are on the transplant waitlist or those who could benefit from a liver transplant.
Not a fit: Patients with chronic liver disease who are not candidates for transplantation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly increase the availability of donor livers for transplantation, potentially saving more lives.
How similar studies have performed: Previous research has shown promising results with supercooling techniques, indicating potential for success in this novel approach.
Where this research is happening
NORTH CHARLESTON, UNITED STATES
- SYLVATICA BIOTECH, INC. — NORTH CHARLESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TAYLOR, MICHAEL JOHN — SYLVATICA BIOTECH, INC.
- Study coordinator: TAYLOR, MICHAEL JOHN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.