Improving liver cell development using a 3D environment
Optimization of the engineered 3D hepatic microenvironment enhances pluripotent stem cell derived hepatocyte
This study is looking at how to grow liver cells from stem cells better by creating a special environment that feels like a real liver, which could lead to better treatments for liver disease and improve how we test new medicines.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10766825 on NIH RePORTER |
What this research studies
This research focuses on enhancing the development of liver cells derived from pluripotent stem cells by optimizing their growth environment. By creating a three-dimensional microenvironment that mimics the natural conditions of the liver, the study aims to improve the maturation and functionality of these cells. This approach could provide a viable alternative to traditional liver transplants and improve drug testing methods. Patients may benefit from advancements in liver disease treatment and management through the development of more effective therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from liver diseases or conditions that may require liver cell therapies.
Not a fit: Patients with acute liver failure requiring immediate transplantation may not benefit from this research in the short term.
Why it matters
Potential benefit: If successful, this research could lead to better treatment options for patients with liver disease by providing a reliable source of functional liver cells.
How similar studies have performed: Other research has shown promise in using engineered environments to enhance cell development, indicating potential success for this approach.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Schwartz, Robert E — Weill Medical Coll of Cornell Univ
- Study coordinator: Schwartz, Robert E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.