Improving live birth rates in women with endometriosis undergoing IVF treatment
Pre-IVF treatment with a GnRH antagonist in women with endometriosis - A prospective double blind placebo controlled trial 2/3
This study is looking at whether a medication called a GnRH antagonist can help women with endometriosis have a better chance of getting pregnant through IVF, and it will compare the results with those who receive a placebo.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10696953 on NIH RePORTER |
What this research studies
This research investigates the effects of a GnRH antagonist on women with endometriosis who are preparing for in vitro fertilization (IVF). The study aims to determine if pre-treatment with this medication can enhance live birth rates compared to a placebo. Participants will be randomly assigned to receive either the GnRH antagonist or a placebo before undergoing IVF-embryo transfer. The research also explores the potential role of specific biomarkers related to endometriosis in predicting treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with endometriosis who are experiencing infertility and are planning to undergo IVF.
Not a fit: Patients who do not have endometriosis or those who are not seeking IVF treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the chances of live births for women with endometriosis undergoing IVF.
How similar studies have performed: While the use of GnRH agonists has been explored, this approach with GnRH antagonists is novel and has not been previously tested for endometriosis-related infertility.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Santoro, Nanette F. — University of Colorado Denver
- Study coordinator: Santoro, Nanette F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.