Improving laser-scanning microscopy for better imaging of living tissues
Official title: New detection paradigms for laser-scanning microscopy leveraging fiber optical amplifiers
Funded at Rockefeller University · NIH-11175528 · Data updated 2026-11-12
This study is working on improving a special type of microscope that helps scientists take better pictures of thick living tissues, making it easier to see details without damaging the tissue, which could be really helpful for understanding health and disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $211,875 |
| NIH project number | 5R21EB036153-03 |
| Project ID | NIH-11175528 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals requiring advanced imaging for conditions related to thick tissues, such as tumors or other biological abnormalities.
✕Less likely to help
Patients with conditions that do not involve thick tissue imaging or those who do not require detailed biological imaging may not benefit from this research.
What this research studies
This research focuses on enhancing laser-scanning microscopy techniques, which are used to image thick, living tissues. By employing advanced optical fiber amplifiers, the project aims to significantly improve the speed and quality of imaging, allowing for deeper penetration and larger fields of view without overheating the tissue. The researchers will construct two specialized detection systems that utilize innovative amplification methods to boost the signal quality and acquisition speed of the imaging process. This could lead to more detailed and accurate observations in biological research.
Why it matters
Potential benefit: If successful, this research could provide patients with improved diagnostic imaging techniques that allow for better monitoring and understanding of various medical conditions.
How similar studies have gone: Other research has shown promise in using optical amplification techniques in imaging, suggesting that this approach could lead to significant advancements in the field.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Demas, Jeffrey Dakin — Rockefeller University
- Study coordinator: Demas, Jeffrey Dakin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.