Improving lab tests to measure NAD+ and related molecules in people having coronary bypass
Development, Validation, and Harmonization of Methods for Collection and Measurement of NAD+ and Related Metabolites: Application to a Randomized Trial of Patients Undergoing Coronary Artery Bypass
This project is developing better ways to collect samples and measure NAD+ and related molecules in adults undergoing coronary artery bypass surgery.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11172609 on NIH RePORTER |
What this research studies
If you take part, researchers may ask for blood or tissue samples around the time of your coronary artery bypass to preserve and measure NAD+, NADH, NADP, NADPH and related metabolites. The team will refine and validate an advanced LC-MS/MS lab method that can measure many NAD-related molecules at once and will standardize how samples are collected and stored so results stay accurate. They will create and use reference materials and isotope-labeled standards so different labs can compare results reliably. The goal is to harmonize methods across labs so future studies can trust and combine their results.
Who could benefit from this research
Good fit: Ideal candidates are adults (21+) scheduled for aortocoronary bypass (coronary artery bypass) who can provide blood or tissue samples around the time of surgery.
Not a fit: People not having cardiac surgery or unwilling to provide perioperative samples are unlikely to receive direct benefit from this methods-focused project.
Why it matters
Potential benefit: If successful, these improved and standardized measurements could help researchers better understand metabolic changes around heart surgery and speed discovery of treatments or biomarkers.
How similar studies have performed: Existing LC-MS/MS approaches already show superior sensitivity and precision, but this project extends prior work by validating a single method for many NAD-related metabolites and creating harmonized reference materials, which is a novel step.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Bhasin, Shalender — Brigham and Women's Hospital
- Study coordinator: Bhasin, Shalender
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.