Improving lab and animal models for invasive lobular breast cancer
Credentialing Models of Invasive Lobular Breast Cancer for Translational Research
This project will refine and compare laboratory and patient-derived models to help researchers find better treatments for people with invasive lobular breast cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11306104 on NIH RePORTER |
What this research studies
The research team will collect and analyze tumor samples, cell lines, patient-derived xenografts (PDX), and mouse models specific to invasive lobular breast cancer (ILC). They will use genetics, bioinformatics, pathology, and immune profiling to determine which models best match human ILC. The investigators will collaborate with national resources like the Cancer Dependency Map (DepMap) and PDXNet to compare many models and share validated models with other scientists. While this work does not test treatments in patients directly, better models should speed up development of ILC-targeted therapies.
Who could benefit from this research
Good fit: Ideal participants would be people with invasive lobular breast cancer who can provide tumor tissue or allow their samples and clinical data to be used in research.
Not a fit: Patients seeking immediate treatment changes or those with other breast cancer types (such as invasive ductal carcinoma) are unlikely to receive direct medical benefit from this preclinical modeling work.
Why it matters
Potential benefit: If successful, this work could speed up reliable testing of new drugs and lead to treatments that better match the biology of ILC.
How similar studies have performed: Related efforts like the Cancer Dependency Map and PDXNet have improved model selection for other cancers, but comprehensive credentialing focused on ILC is relatively new.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Oesterreich, Steffi — University of Pittsburgh at Pittsburgh
- Study coordinator: Oesterreich, Steffi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.