Improving kidney transplant outcomes with bicarbonate treatment
Macula densa NOS1 and transplanted renal graft function
This study is looking at how using bicarbonate might help improve the function of transplanted kidneys, especially those from less-than-ideal donors, by boosting a specific protein that could lead to better long-term success for kidney transplants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10820554 on NIH RePORTER |
What this research studies
This research investigates how bicarbonate treatment can enhance the function of transplanted kidneys by increasing the expression of a specific protein called NOS1 in the macula densa. The study aims to explore the potential of renal alkalization as a method to improve long-term graft survival, particularly for kidneys from marginal donors. By examining the underlying mechanisms, the research seeks to provide new strategies that could benefit both kidney donors and recipients during transplantation. If successful, this approach could lead to better outcomes for patients receiving kidney transplants.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing kidney transplantation, especially those receiving kidneys from marginal donors.
Not a fit: Patients who are not candidates for kidney transplantation or those with functioning kidneys may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the long-term survival of transplanted kidneys, enhancing the quality of life for patients with end-stage kidney disease.
How similar studies have performed: Other research has shown promise in using bicarbonate treatment to improve kidney function, suggesting that this approach may have potential for success.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Wang, Lei — University of South Florida
- Study coordinator: Wang, Lei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.