Improving kidney transplant outcomes in children by analyzing immune responses
Implementation of Eplet Mismatch Analysis in Pediatric Kidney Transplantation
['FUNDING_CAREER'] · JOHNS HOPKINS UNIVERSITY · NIH-11092334
This study is looking at how kids' immune systems react to certain proteins in donor kidneys to help make kidney transplants more successful and reduce the chances of rejection, so that children can have healthier, longer-lasting transplants.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11092334 on ClinicalTrials.gov |
What this research studies
This research focuses on enhancing kidney transplant success in children by analyzing how the immune system responds to specific proteins from donor kidneys. By identifying high-risk mismatches between donor and recipient, the study aims to improve organ allocation strategies, potentially leading to better long-term survival of transplanted kidneys. The research will involve creating a large cohort of pediatric kidney transplant patients and performing detailed genetic testing to understand the immune responses better. This approach could help tailor transplant strategies to minimize the risk of organ rejection due to antibody formation.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are undergoing or are candidates for kidney transplantation.
Not a fit: Patients who are not candidates for kidney transplantation or are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved kidney transplant outcomes and longer-lasting organ function for pediatric patients.
How similar studies have performed: Previous research has shown promise in using similar immunological approaches to improve transplant outcomes, indicating that this methodology has potential for success.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHARNAYA, OLGA — JOHNS HOPKINS UNIVERSITY
- Study coordinator: CHARNAYA, OLGA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.