Improving kidney function after transplantation using heat shock proteins
Targeting heat shock protein 72 to improve renal function after transplantation
['FUNDING_R01'] · UNIV OF ARKANSAS FOR MED SCIS · NIH-11013334
This study is looking at how a special protein can help improve kidney function for people getting transplants, especially from donors who have passed away, by protecting the kidneys during the storage process before the transplant.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF ARKANSAS FOR MED SCIS (nih funded) |
| Locations | 1 site (LITTLE ROCK, UNITED STATES) |
| Trial ID | NIH-11013334 on ClinicalTrials.gov |
What this research studies
This research investigates how targeting heat shock protein 72 can enhance kidney function in patients receiving transplants, particularly from deceased donors. The study focuses on understanding the mechanisms of cold storage injury to kidneys and aims to identify pathways that lead to renal damage. By using a rat model, researchers will explore how heat shock proteins can help maintain protein balance and protect against kidney injury during the preservation process. The ultimate goal is to develop targeted therapies that can be applied during organ preservation to improve transplant outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are receiving kidney transplants from deceased donors.
Not a fit: Patients who are receiving kidney transplants from living donors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved kidney transplant outcomes and reduced mortality associated with transplant procedures.
How similar studies have performed: Similar research has shown promise in using heat shock proteins to improve organ preservation, indicating potential for success in this approach.
Where this research is happening
LITTLE ROCK, UNITED STATES
- UNIV OF ARKANSAS FOR MED SCIS — LITTLE ROCK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PARAJULI, NIRMALA — UNIV OF ARKANSAS FOR MED SCIS
- Study coordinator: PARAJULI, NIRMALA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.