Improving insulin production by addressing placental insufficiency
Prevention of Placental Insufficiency Improves Beta-Cells Function
['FUNDING_R01'] · UNIVERSITY OF ARIZONA · NIH-11045027
This study is looking at how problems with the placenta and slow growth in babies can impact the cells that make insulin, and it aims to find ways to help these cells work better, which could be helpful for those affected by these issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-11045027 on ClinicalTrials.gov |
What this research studies
This research investigates how placental insufficiency and fetal growth restriction affect the development of pancreatic beta cells, which are crucial for insulin production. The study aims to correct low oxygen and glucose levels in fetuses experiencing these conditions, with the goal of enhancing beta-cell function and proliferation. By understanding the mechanisms behind beta-cell dysfunction, the researchers hope to find ways to improve insulin secretion in individuals affected by these developmental issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have experienced fetal growth restriction or placental insufficiency and are now facing challenges related to insulin production.
Not a fit: Patients who do not have a history of fetal growth restriction or placental insufficiency may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved insulin production and better management of Type 2 Diabetes for affected individuals.
How similar studies have performed: Previous research has shown promising results in improving insulin secretion through interventions targeting fetal conditions, suggesting potential success for this approach.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIMESAND, SEAN W — UNIVERSITY OF ARIZONA
- Study coordinator: LIMESAND, SEAN W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus