Improving inhaled gene therapy for lung diseases
Official title: Overcoming Immunological Barriers to Inhaled AAV Gene Therapy
Funded at Tulane University of Louisiana · NIH-10998666 · Data updated 2026-11-12
This study is looking at how to make inhaled gene therapy work better for lung conditions like Cystic Fibrosis and pulmonary arterial hypertension by understanding how the immune system reacts to the treatment, so we can find ways to improve its effectiveness for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | September 30, 2024 |
| Project end | August 29, 2029 |
| Funding year | 2024 |
| Award (this year) | $53,167 |
| NIH project number | 1F30HL176032-01 |
| Project ID | NIH-10998666 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from lung disorders such as Cystic Fibrosis, primary ciliary dyskinesia, or pulmonary arterial hypertension.
✕Less likely to help
Patients with non-lung-related conditions or those who do not respond to inhaled therapies may not benefit from this research.
What this research studies
This research focuses on enhancing the effectiveness of inhaled gene therapy for lung disorders by addressing immune responses that hinder treatment. It investigates how the immune system, particularly B and T cells, reacts to adeno-associated virus (AAV) vectors used in gene therapy. The study aims to understand the unique challenges posed by the lung's immune environment and to develop strategies to overcome these barriers, potentially leading to more successful long-term gene expression in patients with conditions like Cystic Fibrosis and pulmonary arterial hypertension.
Why it matters
Potential benefit: If successful, this research could lead to more effective gene therapies for patients with serious lung diseases.
How similar studies have gone: While gene therapy has shown success in other areas, the specific approach of overcoming immune barriers in lung-directed AAV therapy is relatively novel and has not been extensively tested.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Clark, Robert David Edward — Tulane University of Louisiana
- Study coordinator: Clark, Robert David Edward
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.