NIH-funded research R01 grant

Improving impulsivity by studying brain activity

Official title: Identifying and Targeting Physiological Assays of Circuit Engagement to Improve Impulsivity

Funded at Veterans Medical Research Fdn/san Diego · NIH-11080286 · Data updated 2026-11-12

This study looks at how brain activity connects to impulsivity, which is when people struggle to control their immediate reactions instead of thinking about long-term goals, and it aims to find better treatments for conditions like ADHD and substance abuse that can help those who deal with impulsivity.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionVeterans Medical Research Fdn/san Diego
NIH-funded
Lab location1 site (San Diego, United States)
Project startJuly 1, 2021
Project endApril 30, 2026
Funding year2025
Award (this year)$304,938
NIH project number5R01MH123650-05
Project IDNIH-11080286 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates include individuals diagnosed with ADHD, substance use disorders, or other conditions characterized by impulsivity.

Less likely to help

Patients without impulsivity-related disorders or those not exhibiting significant behavioral inhibition may not benefit from this research.

What this research studies

This research investigates how brain activity relates to impulsivity, which is the inability to control immediate reactions in favor of long-term goals. It focuses on measuring different types of impulsivity, such as motor impulsivity and choice impulsivity, using behavioral tasks and electrophysiological methods. By understanding these mechanisms, the research aims to identify more effective treatments for conditions like ADHD and substance abuse disorders. Patients may benefit from insights that could lead to better-targeted therapies for impulsivity-related issues.

Why it matters

Potential benefit: If successful, this research could lead to improved treatment options for individuals struggling with impulsivity and related disorders.

How similar studies have gone: Previous research has shown promise in using electrophysiological measures to understand impulsivity, suggesting that this approach may yield valuable insights.

Where this research is happening

  • Veterans Medical Research Fdn/san Diego
    San Diego, United States
    Active

Researchers

  • Principal investigator: Ramanathan, Dhakshin — Veterans Medical Research Fdn/san Diego
  • Study coordinator: Ramanathan, Dhakshin

Related research

Other NIH-funded projects on the same topics.

  • PSA Screening: Understanding Benefits and Risks for Black Men

    This grant studies how PSA screening affects Black men to help tailor guidelines and decision-making.

    NIH research Veterans Medical Research Fdn/san Diego · San Diego, United States · NIH-11428699

  • Medial Prefrontal Cortex and Alcohol Relapse in Humans

    A study aims to understand brain factors in relapse to drinking alcohol after abstinence, focusing on the medial prefrontal cortex and blood-brain barrier changes in adults with alcohol use disorder.

    NIH research Veterans Medical Research Fdn/san Diego · San Diego, United States · NIH-11395370

  • How BST2 variants affect HIV defense and help the virus

    This grant studies how HIV tricks the body’s BST2/tetherin defenses and what that means for HIV staying in your body and spreading.

    NIH research Veterans Medical Research Fdn/san Diego · San Diego, United States · NIH-11370701

  • Kidney tubule function and APOL1 in African ancestry people

    A study to understand how kidney tubule health markers relate to kidney disease risk in African ancestry individuals with APOL1 variants.

    NIH research Veterans Medical Research Fdn/san Diego · San Diego, United States · NIH-11364368

  • How breathing machines can harm the kidneys

    Doctors will look at how ventilators change kidney filtering and salt handling in people who are critically ill to help prevent kidney damage.

    NIH research Veterans Medical Research Fdn/san Diego · San Diego, United States · NIH-11349714

  • How SGLT2-blocking diabetes drugs affect kidney filtering and tubule function

    This research looks at how SGLT2-blocking diabetes medicines change tiny blood vessels, tubules, and metabolism inside diabetic kidneys to explain how they slow kidney disease.

    NIH research Veterans Medical Research Fdn/san Diego · San Diego, United States · NIH-11324539

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.