Improving immunotherapy options for colorectal cancer in Nigeria
Research Project
This project seeks to understand why colorectal cancer differs in Nigerian patients so more people there could benefit from immunotherapy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11193508 on NIH RePORTER |
What this research studies
Researchers will compare tumors from Nigerian and U.S. patients to identify immune-related differences, including rates of microsatellite instability (MSI-H). They will analyze tumor tissue, immune cells, and genetic features using laboratory tests and bioinformatics tools to find markers linked to response to immunotherapy. The program will build local testing and research capacity in Nigeria to support future patient diagnosis and treatment decisions.
Who could benefit from this research
Good fit: Adults in Nigeria with colorectal cancer whose tumor samples can be collected and shared with the research program are the ideal candidates for participation.
Not a fit: People without colorectal cancer, those unable to provide tumor samples, or patients whose tumors lack immune-sensitive features are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, the work could help identify Nigerian colorectal cancer patients who are likely to benefit from immunotherapy and expand access to those treatments.
How similar studies have performed: Immunotherapy has shown benefit for MSI-H colorectal cancer in high-income countries, but similar studies are limited in Nigeria, so this effort applies established approaches to a new population.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Kingham, T Peter — Sloan-Kettering Inst Can Research
- Study coordinator: Kingham, T Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.