Improving Immunotherapy for Veterans with Lung Cancer
Repositioning Immunotherapy in Veterans with Lung Cancer
This work explores new ways to give immunotherapy and chemotherapy to Veterans with advanced lung cancer, aiming for more effective and better-tolerated treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11172257 on NIH RePORTER |
What this research studies
For Veterans diagnosed with locally advanced (Stage III) non-small cell lung cancer, current treatments can be difficult to tolerate or may not prevent the cancer from growing. This project looks at giving immunotherapy and chemotherapy before other treatments, a strategy called neoadjuvant therapy, which has shown promise in other cancers. We want to see if this approach can improve how long patients live without their cancer progressing. Additionally, we are exploring using PET scans to guide radiation therapy, potentially making it more precise and easier to handle for Veterans.
Who could benefit from this research
Good fit: Ideal candidates are American war Veterans diagnosed with unresectable Stage III non-small cell lung cancer.
Not a fit: Patients with other types or stages of cancer, or those who are not Veterans, may not directly benefit from this specific research opportunity.
Why it matters
Potential benefit: If successful, this approach could lead to more effective and better-tolerated treatment options for Veterans with advanced lung cancer, potentially improving their survival and quality of life.
How similar studies have performed: Neoadjuvant immunotherapy has shown success in improving outcomes for patients with resectable lung cancer and melanoma, providing a basis for this new approach in unresectable disease.
Where this research is happening
Ann Arbor, United States
- Veterans Health Administration — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Ramnath, Nithya — Veterans Health Administration
- Study coordinator: Ramnath, Nithya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.