Improving immunity to prevent infections in burn patients
Protection Against Nosocomial Infections After Severe Burn Injury Through Trained Immunity
['FUNDING_OTHER'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-11100602
This study is looking at ways to boost the immune system in people who have had severe burn injuries, helping them fight off infections better and stay safe from serious complications.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-11100602 on ClinicalTrials.gov |
What this research studies
This research investigates how to enhance the immune response in patients who have suffered severe burn injuries to prevent infections that can lead to death. The approach focuses on using Toll-like receptor (TLR) agonists, which are substances that can stimulate the immune system, to create a state of 'trained immunity' in immune cells. By understanding how burn injuries affect immune cell function and metabolism, the research aims to develop therapies that can better protect patients from infections caused by antibiotic-resistant pathogens. The study will involve a series of integrated projects to explore these immunomodulatory therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have sustained severe burn injuries and are at high risk for nosocomial infections.
Not a fit: Patients with minor burns or those who do not have a compromised immune system may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of life-threatening infections in severely burned patients.
How similar studies have performed: Previous research has shown promise in using TLR agonists for enhancing immune responses, indicating potential success for this approach.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOHANNON, JULIA K. — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: BOHANNON, JULIA K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Burn injury