Improving immune treatments for acute myeloid leukemia
Understanding mechanisms of impaired immunity in the AML bone marrow
['FUNDING_CAREER'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-11127486
This research aims to understand why the body's immune cells struggle to fight acute myeloid leukemia (AML) in the bone marrow, hoping to make future immune therapies more effective.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11127486 on ClinicalTrials.gov |
What this research studies
We know that immune cells, especially T cells, can sometimes cure AML after a bone marrow transplant, but often they don't work well enough on their own. This project looks closely at the bone marrow of people with AML to discover why their T cells aren't fighting the cancer effectively. We want to find out what makes these T cells weak and how the leukemia cells themselves might be stopping the immune system. By understanding these problems, we hope to find new ways to boost the immune system to better attack AML.
Who could benefit from this research
Good fit: This foundational research is for future patients with acute myeloid leukemia who may benefit from improved immunotherapy approaches.
Not a fit: Patients currently seeking immediate treatment options would not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new and more effective immune-based treatments for patients with acute myeloid leukemia.
How similar studies have performed: Allogeneic hematopoietic cell transplantation has shown that donor T cells can cure AML, and other studies suggest a link between the immune system and AML treatment success.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DEWOLF, SUSAN E — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: DEWOLF, SUSAN E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.