Improving immune responses through T cell modulation
Modulating costimulation pathways to improve follicular helper T cell and antibody responses
This study is looking at how certain signals can help special immune cells called T follicular helper cells work better, which are important for making strong antibodies after vaccinations or infections, so we can find ways to improve vaccines and help people stay healthier.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA New Jersey Health Care System NIH-funded |
| Lab location | 1 site (East Orange, United States) |
| Project ID | NIH-11098423 on NIH RePORTER |
What this research studies
This research investigates how specific pathways can enhance the function of T follicular helper (TFH) cells, which are crucial for producing effective antibodies in response to infections and vaccinations. By examining the roles of costimulatory receptors like CD28 and ICOS, the research aims to understand how different vaccination methods influence TFH cell development and their ability to generate long-lasting immunity. The approach includes in vivo studies to assess the impact of these pathways on TFH cell differentiation and antibody production, ultimately seeking to improve vaccine efficacy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are receiving vaccinations or are at risk of infections requiring enhanced immune responses.
Not a fit: Patients who are not receiving vaccinations or those with compromised immune systems may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective vaccines that provide better protection against infections.
How similar studies have performed: Previous research has shown promising results in enhancing immune responses through modulation of T cell pathways, indicating potential for success in this area.
Where this research is happening
East Orange, United States
- VA New Jersey Health Care System — East Orange, United States (Active)
Researchers
- Principal investigator: Xue, Hai-Hui — VA New Jersey Health Care System
- Study coordinator: Xue, Hai-Hui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.