Improving immune responses through T cell modulation
Official title: Modulating costimulation pathways to improve follicular helper T cell and antibody responses
Funded at VA New Jersey Health Care System · NIH-11098423 · Data updated 2026-11-12
This study is looking at how certain signals can help special immune cells called T follicular helper cells work better, which are important for making strong antibodies after vaccinations or infections, so we can find ways to improve vaccines and help people stay healthier.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA New Jersey Health Care System NIH-funded |
| Lab location | 1 site (East Orange, United States) |
| Project start | January 1, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01BX005771-04 |
| Project ID | NIH-11098423 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are receiving vaccinations or are at risk of infections requiring enhanced immune responses.
✕Less likely to help
Patients who are not receiving vaccinations or those with compromised immune systems may not benefit from this research.
What this research studies
This research investigates how specific pathways can enhance the function of T follicular helper (TFH) cells, which are crucial for producing effective antibodies in response to infections and vaccinations. By examining the roles of costimulatory receptors like CD28 and ICOS, the research aims to understand how different vaccination methods influence TFH cell development and their ability to generate long-lasting immunity. The approach includes in vivo studies to assess the impact of these pathways on TFH cell differentiation and antibody production, ultimately seeking to improve vaccine efficacy.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective vaccines that provide better protection against infections.
How similar studies have gone: Previous research has shown promising results in enhancing immune responses through modulation of T cell pathways, indicating potential for success in this area.
Where this research is happening
-
VA New Jersey Health Care System
East Orange, United States Active
Researchers
- Principal investigator: Xue, Hai-Hui — VA New Jersey Health Care System
- Study coordinator: Xue, Hai-Hui
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.