Improving immune responses against colorectal cancer through targeted therapy
Targeting immunoproteasome-mediated antigen presentation in colorectal cancer immunotherapy
This study is looking at ways to help your immune system better spot and fight colorectal cancer by improving how it recognizes cancer cells, especially for those who haven't had success with current treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11009571 on NIH RePORTER |
What this research studies
This research focuses on enhancing the immune system's ability to recognize and attack colorectal cancer cells by targeting the mechanisms that tumors use to evade immune detection. It investigates how tumor-associated antigens are presented to immune cells and aims to improve this process using innovative therapies. By understanding and manipulating the antigen presentation machinery, the research seeks to boost the effectiveness of existing immunotherapies, particularly for patients who have not responded well to current treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with colorectal cancer who have not responded to standard immunotherapy treatments.
Not a fit: Patients with early-stage colorectal cancer or those who have not yet undergone immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapy options for colorectal cancer patients, potentially improving their survival rates and quality of life.
How similar studies have performed: Previous research has shown promise in enhancing immune responses through targeted therapies, indicating that this approach could yield significant advancements in colorectal cancer treatment.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Zhang, Xinna — Indiana University Indianapolis
- Study coordinator: Zhang, Xinna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.