Improving immune response to prevent tuberculosis in people with HIV
Overcoming restrained lung trafficking by memory CD4+ T cells to prevent active tuberculosis in people living with HIV
This study is looking at how certain immune cells called memory CD4 T cells can be used more effectively to help prevent tuberculosis (TB) in people living with HIV, especially those who have a hidden TB infection, with the goal of improving vaccines and treatments.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10677889 on NIH RePORTER |
What this research studies
This research investigates how memory CD4 T cells can be better utilized to prevent active tuberculosis (TB) in individuals living with HIV. The study focuses on understanding the specific characteristics of these immune cells that contribute to their effectiveness against TB, especially in those who have latent TB infection. By identifying the unique features of protective T cells, the research aims to enhance vaccine development and create targeted therapies. The approach includes analyzing T cell behavior in the lungs of patients to determine how to improve their trafficking and function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who have a latent tuberculosis infection.
Not a fit: Patients who do not have HIV or those who are not infected with tuberculosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for tuberculosis in people living with HIV, potentially saving lives.
How similar studies have performed: Previous research has shown promise in enhancing immune responses against tuberculosis, making this approach a continuation of ongoing efforts in the field.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Carpenter, Stephen Matthew — Case Western Reserve University
- Study coordinator: Carpenter, Stephen Matthew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.