Improving immune response in organ transplantation
Promoting and Visualizing Immune Regulation in Transplantation
This study is looking at ways to help organ transplants work better by understanding how the immune system remembers past transplants, with the goal of finding new treatments that could make it easier for your body to accept a new organ and rely less on medications that suppress your immune system.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11059075 on NIH RePORTER |
What this research studies
This research focuses on enhancing the success of organ transplants by addressing chronic rejection and tolerance issues. It investigates how innate immune memory affects the body's response to transplanted organs and aims to develop new therapies that can improve immune regulation. By targeting specific immune cells and their functions, the research seeks to create a more favorable environment for organ acceptance. Patients may benefit from improved transplant outcomes and reduced reliance on immunosuppressive drugs.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals undergoing or considering allogeneic organ transplantation.
Not a fit: Patients who are not candidates for organ transplantation or those with conditions that preclude successful transplantation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better organ transplant success rates and reduced complications from chronic rejection.
How similar studies have performed: Previous research has shown promise in targeting immune regulation in transplantation, indicating potential for success with this approach.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Camirand, Geoffrey — University of Pittsburgh at Pittsburgh
- Study coordinator: Camirand, Geoffrey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.