Improving immune response in HIV by changing energy metabolism
Re-educating T cell-mediated immunity in SIV by modulating metabolic pathways
This study is looking at whether a common diabetes medication called metformin can help boost the immune cells that fight HIV, making them stronger and more effective in controlling the virus.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10755366 on NIH RePORTER |
What this research studies
This research investigates how modifying metabolic pathways can help rejuvenate T cells that are crucial for controlling HIV infection. The focus is on CD8 T cells, which often become exhausted due to chronic stimulation from the virus. By using the FDA-approved drug metformin, the study aims to see if it can enhance T cell function by reducing mitochondrial stress and improving energy metabolism. Patients may be monitored for changes in their immune response and overall health as a result of this intervention.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who exhibit signs of T cell exhaustion.
Not a fit: Patients who are not infected with HIV or those who do not show signs of T cell exhaustion may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved immune responses in HIV patients, potentially enhancing their ability to control the virus.
How similar studies have performed: While there have been studies on metformin in HIV treatment, this specific approach of targeting T cell metabolism is relatively novel.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Larson, Erica Christine — University of Pittsburgh at Pittsburgh
- Study coordinator: Larson, Erica Christine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.