Improving immune response in burn patients with lung injuries
Multi-modal rescue of pulmonary NRF2-insufficiency after burn and burn + inhalation injury to regulate innate immune dysfunction
This study is looking at how burn injuries, especially when they come with breathing problems, can weaken the immune system and lead to infections, and it's for patients who have experienced these types of injuries to help find better ways to support their recovery and keep them healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11075317 on NIH RePORTER |
What this research studies
This research investigates how burn injuries, especially when combined with inhalation injuries, affect the immune system and increase the risk of infections in patients. The team aims to understand the mechanisms behind uncontrolled inflammation and how to restore immune balance after such injuries. By studying both human samples and animal models, they hope to develop better prediction models for infection risk and therapeutic strategies to enhance recovery and reduce complications. The ultimate goal is to improve patient outcomes and decrease mortality associated with burn injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have suffered burn injuries, particularly those with inhalation injuries.
Not a fit: Patients with burn injuries who do not have any respiratory complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance the immune response in burn patients, reducing their risk of infections and associated complications.
How similar studies have performed: Previous research has shown promise in understanding immune responses in burn injuries, but this specific approach to restoring immune homeostasis is relatively novel.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Maile, Robert — University of Florida
- Study coordinator: Maile, Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.