Improving immune response in aggressive breast cancer by targeting tumor-associated macrophages
Combating the Immunosuppressive Tumor Microenvironment in Triple Negative Breast Cancer: The Role of Mitochondrial Dynamics in the Polarization of Tumor-Associated Macrophages
This study is looking at ways to help the immune system fight Triple Negative Breast Cancer by changing certain immune cells to better attack the cancer, which could lead to new treatments that help patients feel better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10994650 on NIH RePORTER |
What this research studies
This research focuses on Triple Negative Breast Cancer (TNBC), a type of breast cancer known for its aggressive nature and poor prognosis. The study aims to enhance the immune response against TNBC by repolarizing tumor-associated macrophages, which are immune cells that can either promote or inhibit tumor growth. By understanding how mitochondrial dynamics influence these macrophages, the research seeks to shift them from a pro-tumor state to a cytotoxic, anti-tumor state. This approach could lead to new therapeutic strategies that improve patient outcomes in TNBC.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with Triple Negative Breast Cancer, particularly those with advanced or metastatic disease.
Not a fit: Patients with non-breast cancers or those with breast cancer subtypes other than Triple Negative may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with Triple Negative Breast Cancer, potentially improving survival rates.
How similar studies have performed: Other research has shown promise in enhancing immune responses in cancer through similar approaches, indicating potential for success in this area.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Chan, Hilda Lyn — Baylor College of Medicine
- Study coordinator: Chan, Hilda Lyn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.