Improving immune response against pediatric gliomas using a virus-based vaccine
Diversity Supplement: Hernandez-Aguirre- Cripe U54
This study is testing a new treatment that uses a specially designed virus to help kids with brain tumors called gliomas by boosting their immune system to better recognize and fight the cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project ID | NIH-10533425 on NIH RePORTER |
What this research studies
This research focuses on enhancing the immune system's ability to recognize and attack pediatric gliomas, a type of brain tumor. The approach involves using a specially engineered virus that can stimulate immune cells and express tumor-associated antigens, which helps the immune system identify and target cancer cells more effectively. By addressing challenges such as low mutation rates and immunosuppressive environments in these tumors, the research aims to develop a more effective immunotherapeutic strategy. Patients may benefit from a novel treatment that could improve their immune response to these difficult-to-treat tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are pediatric patients diagnosed with malignant gliomas who are 21 years old or younger.
Not a fit: Patients with non-glioma tumors or those older than 21 years may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for pediatric gliomas, potentially improving survival rates and quality of life for affected children.
How similar studies have performed: Previous research has shown promise in using virus-based therapies to enhance immune responses against tumors, indicating a potential for success in this novel approach.
Where this research is happening
Columbus, United States
- Research Inst Nationwide Children's Hosp — Columbus, United States (Active)
Researchers
- Principal investigator: Cripe, Timothy P — Research Inst Nationwide Children's Hosp
- Study coordinator: Cripe, Timothy P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.