Improving immune response against brain tumors
Official title: Regulation of Tumor Immunogenicity in Glioblastoma
Funded at University of California, San Francisco · NIH-11036402 · Data updated 2026-11-12
This study is looking at how to boost the immune system's fight against glioblastoma, a tough brain tumor, by tweaking certain proteins in the tumor cells so that T cells can better spot and attack them, which could lead to better treatments for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | April 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $409,785 |
| NIH project number | 5R01NS131545-03 |
| Project ID | NIH-11036402 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with glioblastoma who are 21 years or older.
✕Less likely to help
Patients with other types of brain tumors or those who are not eligible for immunotherapy may not benefit from this research.
What this research studies
This research investigates ways to enhance the immune system's ability to fight glioblastoma, a highly aggressive brain tumor. The approach focuses on understanding how certain proteins in tumor cells can be modified to increase their visibility to T cells, which are crucial for an effective immune response. By inhibiting a specific protein called PP2A, the researchers aim to improve the expression of molecules that help T cells recognize and attack the tumor. This could potentially lead to more effective immunotherapy treatments for patients with glioblastoma.
Why it matters
Potential benefit: If successful, this research could lead to new immunotherapy strategies that significantly improve survival rates for patients with glioblastoma.
How similar studies have gone: Previous research has shown that enhancing immune responses in glioblastoma through similar mechanisms has potential, but this specific approach is still being explored.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Ho, Sze Chun Winson — University of California, San Francisco
- Study coordinator: Ho, Sze Chun Winson
Related research
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Small molecules to block Slit2/ROBO in glioblastoma
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Immunotherapy for glioblastoma: advancing treatment and understanding
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6-thio-2'-deoxyguanosine for glioblastoma: a new approach to target tumors before surgery
A trial tests a novel drug given before glioblastoma surgery to see how it behaves in the body and within the tumor, and to learn how it affects cancer cells and the immune environment.
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CD38-Driven Changes in Brain Tumor Metabolism and Immunity in Glioblastoma
A patient-facing look at how scientists plan to study how glioblastoma grows by changing its metabolism and dampening the immune response, with potential targets to help treatment in the future.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.