Improving immune recovery after stem cell transplants.
Enhancing Innate Immune Reconstitution Post Allogeneic HSCT.
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10878786
This study is looking at ways to help boost the immune system recovery for patients who have had a stem cell transplant, focusing on certain immune cells that need more support to grow back properly, so that patients can have better health outcomes after their treatment.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10878786 on ClinicalTrials.gov |
What this research studies
This research investigates how to enhance the recovery of the immune system in patients who have undergone allogeneic hematopoietic stem cell transplantation (allo-HSCT). The study focuses on understanding the role of specific immune cells, particularly innate lymphoid cells (ILC), that are not fully restored after transplantation. By exploring the mechanisms that limit the development of these cells, the research aims to identify strategies to improve immune reconstitution and overall patient outcomes. Patients may be involved in trials that test new approaches to support their immune recovery post-transplant.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have undergone allogeneic stem cell transplantation for conditions like acute leukemia.
Not a fit: Patients who have not undergone stem cell transplantation or those with conditions unrelated to immune recovery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved immune recovery for patients after stem cell transplants, potentially reducing complications and improving survival rates.
How similar studies have performed: Previous research has shown promise in enhancing immune recovery through various interventions, indicating that this approach may yield beneficial results.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SERODY, JONATHAN S. — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: SERODY, JONATHAN S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.