Improving immune defense against Chlamydia infections in women.
Official title: Enhancing memory T cell defense in the female reproductive tract.
Funded at Emory University · NIH-10983807 · Data updated 2026-11-12
This study is looking at ways to boost the immune system in women's reproductive health to help fight off Chlamydia, a common infection that can lead to serious issues like infertility and chronic pain, and it hopes to find new ways to improve vaccines and treatments.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | December 1, 2023 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $189,756 |
| NIH project number | 5R21AI180610-02 |
| Project ID | NIH-10983807 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women, particularly those at risk for Chlamydia infections or experiencing recurrent infections.
✕Less likely to help
Patients who are not at risk for Chlamydia infections or those who have already developed severe complications may not benefit from this research.
What this research studies
This research focuses on enhancing the immune response in the female reproductive tract to better defend against Chlamydia trachomatis, a common sexually transmitted infection. By investigating how memory T cells can be localized and activated in this area, the study aims to improve the body's ability to clear infections and reduce the risk of severe complications such as infertility and chronic pain. The approach involves using animal models to understand the mechanisms that support the survival and effectiveness of these immune cells. If successful, this research could lead to new strategies for vaccination and treatment.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of severe health complications associated with Chlamydia infections in women.
How similar studies have gone: Previous research has shown promise in enhancing immune responses through memory T cell activation in other contexts, suggesting potential for success in this area as well.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Kohlmeier, Alison Swaims — Emory University
- Study coordinator: Kohlmeier, Alison Swaims
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.