Improving imaging techniques to study cellular processes in diseases like Alzheimer's.
Official title: Two-photon fluorescence lifetime imaging microscopy utilizing the space-time duality
Funded at University of Colorado · NIH-11089550 · Data updated 2026-11-12
This study is working on a new way to take pictures of cells that helps us see how they work, especially in conditions like Alzheimer's and age-related eye problems, so that doctors can better understand these diseases and improve how they diagnose and treat patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project start | June 2, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $106,374 |
| NIH project number | 5R21EB033084-03 |
| Project ID | NIH-11089550 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or age-related macular degeneration.
✕Less likely to help
Patients with conditions unrelated to cellular metabolism or those not affected by Alzheimer's or age-related macular degeneration may not benefit from this research.
What this research studies
This research focuses on enhancing fluorescence lifetime imaging microscopy (FLIM), a technology that provides detailed insights into cellular processes by measuring the behavior of fluorescent molecules. By increasing the imaging speed and efficiency, the study aims to better understand cellular metabolism, protein interactions, and the biological environment in conditions such as Alzheimer's disease and age-related macular degeneration. Patients may benefit from improved diagnostic techniques and a deeper understanding of their conditions through this advanced imaging approach.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and faster diagnostic tools for diseases like Alzheimer's and age-related macular degeneration.
How similar studies have gone: Previous research has shown promise in enhancing imaging techniques for cellular studies, indicating potential success for this novel approach.
Where this research is happening
-
University of Colorado
Boulder, United States Active
Researchers
- Principal investigator: Huang, Shu-Wei — University of Colorado
- Study coordinator: Huang, Shu-Wei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.