Improving imaging techniques to study blood vessel problems in Alzheimer's disease.
Official title: High-resolution cerebral microvascular imaging for characterizing vascular dysfunction in Alzheimer's disease mouse model
Funded at University of Illinois at Urbana-Champaign · NIH-10848559 · Data updated 2026-11-12
This study is looking at how problems with blood vessels might play a role in Alzheimer's disease by using special imaging techniques to see how these vessels interact with a protein linked to the disease, and it aims to help us understand more about Alzheimer's and find new ways to treat it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Urbana-Champaign NIH-funded |
| Lab location | 1 site (Champaign, United States) |
| Project start | July 15, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $574,742 |
| NIH project number | 1R56NS131516-01 |
| Project ID | NIH-10848559 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with Alzheimer's disease or those at risk of developing it.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research focuses on understanding how blood vessel dysfunction contributes to Alzheimer's disease by using advanced imaging techniques. The study aims to investigate the interactions between blood vessels and amyloid-beta, a protein associated with Alzheimer's, in a mouse model. By enhancing imaging resolution and depth, researchers hope to visualize vascular changes in the brain that are linked to the disease. This approach could lead to a better understanding of the mechanisms behind Alzheimer's and inform the development of new therapies.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating Alzheimer's disease by targeting vascular dysfunction.
How similar studies have gone: Other research has shown promising results in using advanced imaging techniques to study vascular issues in neurodegenerative diseases, indicating potential for success in this area.
Where this research is happening
-
University of Illinois at Urbana-Champaign
Champaign, United States Active
Researchers
- Principal investigator: Llano, Daniel a — University of Illinois at Urbana-Champaign
- Study coordinator: Llano, Daniel a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.