Improving imaging techniques to observe single molecules in living cells
Official title: Toward high spatiotemporal resolution models of single molecules for in vivo applications
Funded at Arizona State University-Tempe Campus · NIH-11045707 · Data updated 2026-11-12
This study is working on improving ways to see tiny molecules inside living cells more clearly, which could help doctors track treatments and diagnose diseases better, all while being gentle on the cells being observed.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project start | March 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $292,998 |
| NIH project number | 5R35GM148237-03 |
| Project ID | NIH-11045707 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that require precise monitoring of cellular processes, such as cancer or genetic disorders.
✕Less likely to help
Patients with conditions that do not involve cellular imaging or those who are not undergoing treatment that requires monitoring at the molecular level may not benefit from this research.
What this research studies
This research focuses on enhancing imaging methods to observe single molecules within living cells at high resolution. By addressing challenges related to noise and data interpretation, the project aims to develop new mathematical tools that can improve the accuracy of fluorescence imaging. This could lead to better monitoring of therapeutic agents and more effective disease diagnostics. The approach involves innovative techniques that minimize the amount of light needed, reducing potential damage to samples during observation.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in how diseases are diagnosed and treated by providing clearer insights into cellular processes.
How similar studies have gone: Previous research has shown success in enhancing imaging techniques for single molecules, indicating that this approach has potential for further breakthroughs.
Where this research is happening
-
Arizona State University-Tempe Campus
Tempe, United States Active
Researchers
- Principal investigator: Presse, Steve — Arizona State University-Tempe Campus
- Study coordinator: Presse, Steve
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.