Improving imaging techniques for heart and muscle tissues using advanced X-ray technology
Official title: Expanding synchrotron applications in biomedical research: Myocardial and skeletal muscle imaging at Brookhaven National Labs
Funded at Accelerated Muscle Biotechnologies Consultants, L.l.c. · NIH-11007351 · Data updated 2026-11-12
This study is working on a new way to take detailed pictures of proteins in living muscles, which could help scientists understand how muscles work better and eventually lead to improved treatments for muscle-related issues.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Accelerated Muscle Biotechnologies Consultants, L.l.c. NIH-funded |
| Lab location | 1 site (Mansfield, UNITED STATES) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $311,168 |
| NIH project number | 1R43GM156170-01 |
| Project ID | NIH-11007351 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with muscle-related diseases or conditions, particularly those affecting cardiac and skeletal muscles.
✕Less likely to help
Patients with non-muscle-related conditions or those who do not have access to the research facilities may not receive any benefit from this research.
What this research studies
This research focuses on enhancing the use of high-powered synchrotron radiation, specifically muscle small-angle X-ray scattering (MyoSAXS), to directly image the organization of proteins in live skeletal and cardiac muscle tissues. By developing infrastructure at Brookhaven National Labs, the project aims to make this advanced imaging technique more accessible to researchers who may not have the expertise to operate synchrotron facilities. The goal is to facilitate better understanding of muscle mechanics and support drug development efforts. Patients may benefit indirectly through improved research outcomes that could lead to better treatments for muscle-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for conditions affecting skeletal and cardiac muscles.
How similar studies have gone: While the application of MyoSAXS in clinical settings is still emerging, there have been successful applications in academic research, indicating potential for future breakthroughs.
Where this research is happening
-
Accelerated Muscle Biotechnologies Consultants, L.l.c.
Mansfield, United States Active
Researchers
- Principal investigator: Nguyen, Khoi Dac — Accelerated Muscle Biotechnologies Consultants, L.l.c.
- Study coordinator: Nguyen, Khoi Dac
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.