Improving imaging techniques for eye diseases related to aging
Official title: Multimodal Molecular Imaging of Choroidal Neovascularization
Funded at Johns Hopkins University · NIH-11173966 · Data updated 2026-11-12
This study is working on new ways to take pictures of the eye to better understand and track a serious eye condition called wet age-related macular degeneration, which can cause vision loss, so that patients can eventually have better tools and treatments to help them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 30, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $690,964 |
| NIH project number | 7R01EY034325-02 |
| Project ID | NIH-11173966 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with wet age-related macular degeneration or those at risk of developing this condition.
✕Less likely to help
Patients with dry age-related macular degeneration or other unrelated eye conditions may not benefit from this research.
What this research studies
This research focuses on developing advanced imaging methods to better understand and monitor choroidal neovascularization (CNV), a major cause of vision loss in patients with wet age-related macular degeneration (AMD). By creating a new rabbit model that mimics persistent disease activity, the researchers aim to use multimodal imaging techniques, including photoacoustic microscopy and optical coherence tomography, to track disease progression and response to treatments. This non-invasive approach will allow for more accurate assessments of potential new therapies for AMD. Patients may benefit from improved diagnostic tools and treatment options as a result of this work.
Why it matters
Potential benefit: If successful, this research could lead to better monitoring and treatment strategies for patients suffering from age-related macular degeneration.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques for monitoring eye diseases, indicating that this approach may yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Paulus, Yannis Mantas — Johns Hopkins University
- Study coordinator: Paulus, Yannis Mantas
Related research
Other NIH-funded projects on the same topics.
-
Targeting hidden brain injuries in iTTP to improve long-term brain health
A researcher aims to find out how silent brain injuries in people with immune thrombotic thrombocytopenic purpura (iTTP) happen, how they affect thinking and stroke risk, and how to prevent them.
-
Accelerated flap coverage for severe leg injuries: earlier reconstruction vs standard timing
This study tests whether doing early flap coverage after a severe leg injury lowers infection risk and improves healing for patients with open wounds and bone injury.
-
Placebo-controlled shunting for iNPH: does the surgery help with walking and balance?
A doctor-led trial at Johns Hopkins will test whether a shunt surgery improves walking and balance in older adults with idiopathic normal pressure hydrocephalus.
-
Omalizumab for COPD patients with allergen sensitization and exposure
A multicenter trial will test whether adding omalizumab helps people with COPD who are allergic to common indoor allergens and are exposed to them.
-
Johns Hopkins Total Worker Health Center focusing on mental health
A nationwide center at Johns Hopkins is working to improve mental health and well-being among workers by studying workplace health strategies and translating findings into practical tools.
-
Role of fat droplets in liver fat and inflammatory signals in NAFLD
A study at Johns Hopkins will explore how fat droplets in the liver influence molecules that drive inflammation and progression of non-alcoholic fatty liver disease (NAFLD) in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.