Improving imaging techniques for eye diseases related to aging
Multimodal Molecular Imaging of Choroidal Neovascularization
This study is working on new ways to take pictures of the eye to better understand and track a serious eye condition called wet age-related macular degeneration, which can cause vision loss, so that patients can eventually have better tools and treatments to help them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11173966 on NIH RePORTER |
What this research studies
This research focuses on developing advanced imaging methods to better understand and monitor choroidal neovascularization (CNV), a major cause of vision loss in patients with wet age-related macular degeneration (AMD). By creating a new rabbit model that mimics persistent disease activity, the researchers aim to use multimodal imaging techniques, including photoacoustic microscopy and optical coherence tomography, to track disease progression and response to treatments. This non-invasive approach will allow for more accurate assessments of potential new therapies for AMD. Patients may benefit from improved diagnostic tools and treatment options as a result of this work.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with wet age-related macular degeneration or those at risk of developing this condition.
Not a fit: Patients with dry age-related macular degeneration or other unrelated eye conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better monitoring and treatment strategies for patients suffering from age-related macular degeneration.
How similar studies have performed: Previous research has shown promise in using advanced imaging techniques for monitoring eye diseases, indicating that this approach may yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Paulus, Yannis Mantas — Johns Hopkins University
- Study coordinator: Paulus, Yannis Mantas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.